Conolidine’s analgesic effects stem from its conversation with non-opioid pain pathways. As opposed to opioids, which bind to µ-opioid receptors within the central anxious process, conolidine modulates alternate molecular targets. A Science Improvements research found that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://raymondrcfhj.blog-eye.com/39104655/not-known-factual-statements-about-alternative-natural-pain-relief-to-replace-traditional-painkillers