Not all individuals with CLL require therapy. Irrespective of all current advancements, the iwCLL still suggests watchful observation for people with asymptomatic disease.86 This advice is based on at the very least two randomized trials comparing observation to both chlorambucil monotherapy or fludarabine, cyclophosphamide and rituximab (FCR).103,104 Both equally trials https://jasperteluc.dm-blog.com/32522933/the-smart-trick-of-mbl77-that-nobody-is-discussing