Not all patients with CLL require therapy. Even with all latest innovations, the iwCLL nonetheless suggests watchful observation for patients with asymptomatic disease.86 This advice is based on no less than two randomized trials comparing observation to possibly chlorambucil monotherapy or fludarabine, cyclophosphamide and rituximab (FCR).103,104 Both trials concluded that https://paulv988mzn5.blogoxo.com/profile